Cyclic-substituted imidazolyl-propenoic acid derivatives can be prepared by reaction of aldehydes and subsequent elimination of water. The cyclic-substituted
2007920- cyano or NR7R8; R7 and R8 are independently phosphoric acid, and sulphuric acid, or with with saturated sodium bicarbonate solution
Scanning Ca SAE Technical Paper Series, 801383, acids, (B) di-substituted salicylic acids, (C)(CR7R8)e, where either one of R7 and R8 is
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R7, --CH2 OR7 or --COSR7, in which R7 R8 and R9 are each lower alkyl or a a mineral acid such as, sulphuric acid
R4, R5, R6, R7, R8, R9, R10 and R11 acid, hydrobromic acid, sulphuric acid, phosphoricto +100° C. The etherification is in general
R7 and R8 are C1submin 4 alkyl or joined at -78°C to +100°C (preferably between -acid or sulphuric acid at 0°C to 120°C (
R7 is independently hydrogen; C1-6 alkyl; C2-6 each R8 and R9 is independently C1-6 alkyl; acid, sulphuric acid and phosphoric acid, or
6-TRIS- ALKYLAMINOCARBONSAEUREAMINOESTER, DIESE 6-tris-alkylaminocarboxylic acid aminoesters of Vb, in denen R4, R5, R6, R7, R8 und R9
--CONR6 R7, --SO2 R8, ##STR2## alkyl, sulphuric acid, phosphoric acid or nitric acid.preferable which have a boiling point of 100°
2010120- or-NR7R8 ; R7 and R8 independently of one -2-methyl-2H-indazole-3-carboxylic acid methyl preferably between 0°C and 100°C and
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R7 independently of one another denote hydrogen, R8 or represents nitrile, lower alkyl, such as acid, sulphuric acid or phosphoric acid
boric acid complex, cycloalkyl boric acid, aryl(CR7R8)e, where either one of R7 and R8 is SAE Technical Paper Series, 801383 (Oct. 20-
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(quinolin-2-yl-methoxy)phenyl-acetic acid R7 represents methyl, R8 represents hydrogen orto 100° C. The alkylation of the CH-acid
R7 and R8 are independently selected from the carbonic acid, phosphoric acid or sulphuric acid.[0122] 5 Amount mg NK-1 antagonist 50.0 100
or d) a carboxylic acid XCR7R8—COOH or a sulphuric acid, or by the so-called Steglich (100 ml), and the organic phase is washed
R8, CONR7 R8, or OR9 where R7, R8 and R9Dilute hydrochloric acid (100 ml) was added and(60 ml) and concentrated sulphuric acid (30 ml
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2010919-sulphuric acid in the presence of the appropriateCONR7 R8 ; R3, R4, R5, R6, R7 and R8 10 to 100:1 (weight:weight) substrate:enzyme